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J. Biochem, 1988, Vol. 103, No. 2 281-285
© 1988 Japanese Biochemical Society

research-article

Gene Structure of Human Thrombomodulin, a Cofactor for Thrombin Catalyzed Activation of Protein C1

Takashi Shirai*, Satoshi Shiojiri*, Hirataka Ito*, Shuji Yamamoto*, Hiroshi Kusumoto**, Yoshihiro Deyashiki**, Ikuro Maruyama*** and Koji Suzuki**,2

*Bio-Science Laboratory, Life Science Research Laboratories, Asahi Chemical Industry Fuji, Shizuoka 416
**Department of Laboratory Medicine, Mie University School of Medicine Tsu, Mie 514
***Third Department of Internal Medicine, Kagoshima University School of Medicine Kagoshima, Kagoshima 890

2To whom correspondence should be addressed.

The gene coding for human thrombomodulin, a thrombin receptor on endothelial cells and a cofactor for the activation of anticoagulant protein C zymogen, was isolated from a human genomic library by employing human thrombomodulin cDNA as a probe. The nucleotide sequences of the gene and the adjacent 5' and 3' flanking regions were then determined. The nucleotide sequence of this gene with approximately 3.7 kilobase pairs was identical to that of the cDNA, indicating that the gene for human thrombomodulin is free of introns. Hybridization data showed that there is only a single thrombomodulin gene in the human genome.

1This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan, and by grants from the Naito Foundation and the Research Foundation for Cancer and Cardiovascular Disease.


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