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J. Biochem, 1988, Vol. 103, No. 4 581-582
© 1988 Japanese Biochemical Society

other

Phosphatidic Acid-Induced Calcium Mobilization in Osteoblasts1

Tomoyuki Kawase and Akitoshi Suzuki

Department of Pharmacology, Niigata University School of Dentistry Niigata, Niigata 951

Phosphatidic acid (PA) evoked a transient increase in the cytosolic free Ca2+ concentration ([Ca2+]1) in osteoblasts isolated from neonatal mouse calvaria. This increase was observed in both low (below 150 µM) and high (1.26 mM) Ca2+-containing medium. In contrast, other phospholipids, such as phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositol, failed to increase [Ca2+]1 in osteoblasts. In high Ca2+-containing medium, A23187 [GenBank] also increased [Ca2+]1 in the cells, but the mode of the change was different from that in the case of PA. These results suggest that PA may induce Ca2+-mediated cellular responses through Ca2+ release from intracellular stores in osteoblasts.

1 This study was supported in part by Grants-in-Aid (No. 62480375) from the Ministry of Education, Science and Culture of Japan.


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