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J. Biochem, 1988, Vol. 103, No. 4 735-739
© 1988 Japanese Biochemical Society

research-article

Inhibitory Effect of Sarcotoxin IIA, an Antibacterial Protein of Sarcophaga peregrina, on Growth of Escherichia coli1

Keiichi Ando, Faculty of Pharmaceutical Sciences and Shunji Natori, Faculty of Pharmaceutical Sciences2

The University of Tokyo Bunkyo-ku, Tokyo 113

2To whom correspondence should be addressed.

The effect of sarcotoxin IIA, an antibacterial protein of Sarcophaga peregrina (flesh fly), on Escherichia coli was investigated. Sarcotoxin IIA was found to have a bacterial effect on growing bacteria, but little on non-growing bacteria. At a concentration of 25 µg/ml, it induced significant morphological change of growing E. coli cells. In its presence, growing cells became greatly elongated, and spheroplast-like bulges and projections appeared on their surface. A rough mutant strain of E. coli with a defect in the structure of lipopolysac-charide was more sensitive than the parent strain to sarcotoxin IIA. These results suggest that the main effect of sarcotoxin IIA is to inhibit cell wall synthesis, including septum formation.

1This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.


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