Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Endo, T.
Right arrow Articles by Kobata, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Endo, T.
Right arrow Articles by Kobata, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

J. Biochem, 1988, Vol. 103, No. 6 1035-1038
© 1988 Japanese Biochemical Society

research-article

Altered Glycosylation Is Induced in Both {alpha}- and ß-Subunits of Human Chorionic Gonadotropin Produced by Choriocarcinoma1

Tamao Endo*, Ryuichiro Nishimura**, Matsuto Mochizuki**, Naohisa Kochibe*** and Akira Kobata*

* Department of Biochemistry, the Institute of Medical Science, The University of Tokyo Minato-ku, Tokyo 108
** Department of Obstetrics and Gynecology, Kobe University School of Medicine Chuo-ku, Kobe, Hyogo 650
*** Department of Biology, Faculty of Education, Gunma University Maebashi, Gunma 371

The two subunits of human chorionic gonadotropin (hCG) purified from the urine of a patient with choriocarcinoma were successfully separated by SDS-polyacrylamide gel electrophoresis. A comparative study of the oligosaccharides released from the two subunits by hydrazinolysis revealed that altered glycosylation occurs in both subunits and possibly at all four asparagine sites of the choriocarcinoma hCG molecule.

1This work was supported in part by a Grant-in-Aid for Special Project Research (Cancer-Bioscience) from the Ministry of Education, Science and Culture of Japan.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.