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J. Biochem, 1988, Vol. 103, No. 6 901-902
© 1988 Japanese Biochemical Society

other

Elevation of Cytosolic Free Ca2+ Is Directly Evoked by Thromboxane A2 in Human Platelets during Activation with Collagen1

Tatsuya Moriyama*, Hitoshi Takamura*, Hiroshi Narita*, Ken-ichi Tanaka**, Takao Matsuura** and Makoto Kito*,2

*Research Institute for Food Science, Kyoto University Uji, Kyoto 611
**Kyoto Red Cross Blood Center Higashiyama-ku, Kyoto, Kyoto 605

2To whom correspondence should be addressed.

The thromboxane A2 antagonist, ONO-3708, completely inhibited the increase in cytosolic free Ca2+ in human platelets during activation with collagen. Half-maximal Ca2+ release and influx required about 3 and 4 nM STA2, a stable thromboxane A2 mimetic, respectively. However, half maximal activation of phospholipase C required about 18 nM STA2. This suggests that thromboxane A2 directly causes Ca2+ mobilization without further activation of phospholipase C during activation of human platelets with collagen.

1This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.


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