Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Kobayashi, Y.
Right arrow Articles by Go, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kobayashi, Y.
Right arrow Articles by Go, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

J. Biochem, 1988, Vol. 104, No. 3 322-325
© 1988 Japanese Biochemical Society

other

The Conformation of {alpha}-Human Atrial Natriuretic Polypeptide in Solution

Yuji Kobayashi*,1, Tadayasu Ohkubo*, Yoshimasa Kyogoku*, Satoshi Koyama**, Masakazu Kobayashi** and Nobuhiro Go***

*Institute for Protein Research, Osaka Uniuersity Suita, Osaka 56
**Research Laboratories, Fujisawa Phannaceutical Co., Ltd. Kashima, Yodogawa-ku, Osaka, Osaka 532
***Faculty of Science, Kyoto University Sakyo-ku,Kyoto, Kyoto 606

1To whom correspondence should be addressed

The three-dimensional structure of {alpha}-human ANP in solution was determined through the combined use of nuclear magnetic resonance spectroscopy and distance geometry. The results are based on distance constraints determined by nuclear Overhauser effect measurements and one disulfide bond. The structure is as follows. Three separate regions, which are Ser1-Cys7, Arg11-Ile15, and Gln18-Tyr28 each have some ordered structure. The remaining parts in the sequences of Gly9-Glyl0 and Gly16-Ala17 act as hinges. And the C-terminal part is folded back toward the cyclic moiety. The conformation of {alpha}-hANP reported here is expected to give a better understanding of the relationships between its biological activities and three-dimensional structure.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.