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J. Biochem, 1990, Vol. 107, No. 5 699-702
© 1990 Japanese Biochemical Society

research-article

Fatty Acyl-CoAs Are Potent Inhibitors of the Nuclear Thyroid Hormone Receptor In Vitro

Qiulin Li, Naoki Yamamoto, Akira Inoue1 and Seiji Morisawa

Department of Biochemistry, Osaka City University Medical School Abeno-ku, Osaka, Osaka 545

1To whom correspondence should be addressed.

We report that long-chain fatty acyl-CoAs are potent inhibitors of the thyroid hormone(T3) receptor isolated from rat liver nuclei. Both saturated and unsaturated fatty acyl-CoAs were similarly potent. Fifty per cent inhibition of T3 binding by the receptor was observed at an oleoyl-CoA concentration as low as 1.3 µM, and the affinity of oleoyl-CoA for the receptor (K1) was estimated to be 0.45 µM, Fatty acyl-CoAs also promoted dissociation of the hormone bound to the receptor. The action of fatty acyl-CoAs was competitive for the hormone binding site, resulting in a reduction in the receptor's affinity for T3. These observations suggest that fatty acyl-CoAs modulate the binding of the thyroid hormone to its nuclear receptor, in vitro. Whether or not such events occur in vivo remains to be determined.


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