J. Biochem, 1996, Vol. 119, No. 4 591-600
© 1996 Japanese Biochemical Society
review-article |
Emerging Multipotent Aspects of Hepatocyte Growth Factor
Division of Biochemistry, Biomedical Research Center, Osaka University Medical School Suita, Osaka 565
1To whom correspondence should be addressed. Fax: +81-6-879-3789
Specific tissue interactions between epithelia and mesenchyme (or stroma), e.g., epithelial-mesenchymal (or -stromal) interactions mediate crucial aspects of normal development and tissue regeneration. These events affect tissue induction, organogenesis, cell movement, and morphogenesis of multicellular structures. Extensive and diverse studies have established that hepatocyte growth factor (HGF), a ligand for the c-met protooncogene product of receptor tyrosine kinase, is a mesenchymal- or stromal-derived multipotent polypeptide which mediates epithelial-mesenchymal interactions. During embryogenesis, HGF supports organogenesis and morphogenesis of various tissues and organs, including the liver, kidney, lung, gut, mammary gland, tooth, skeletal system, etc. In adult tissues, HGF elicits a potent organotrophic function which supports regeneration of organs including the liver, kidney, and lung. In the brain, HGF is a new member of the family of neurotrophic factors. In neoplastic tissue, HGF is involved in tumor invasion and metastasis, through tumor-stromal interactions. While HGF was originally identified as a potent mitogen for mature hepatocytes, the biological functions of this factor reach far beyond the original identifications. Such being the case, use of HGF for purposes of therapeutics is being given increasing attention.
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T. Otsuka, J. Jakubczak, W. Vieira, D. P. Bottaro, D. Breckenridge, W. J. Larochelle, and G. Merlino Disassociation of Met-Mediated Biological Responses In Vivo: the Natural Hepatocyte Growth Factor/Scatter Factor Splice Variant NK2 Antagonizes Growth but Facilitates Metastasis Mol. Cell. Biol., March 15, 2000; 20(6): 2055 - 2065. [Abstract] [Full Text]
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 F. Blanquaert, R. C. Pereira, and E. Canalis Cortisol inhibits hepatocyte growth factor/scatter factor expression and induces c-met transcripts in osteoblasts Am J Physiol Endocrinol Metab, March 1, 2000; 278(3): E509 - E515. [Abstract] [Full Text] [PDF]
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 J. A. Parrott and M. K. Skinner Expression and Action of Hepatocyte Growth Factor in Human and Bovine Normal Ovarian Surface Epithelium and Ovarian Cancer Biol Reprod, March 1, 2000; 62(3): 491 - 500. [Abstract] [Full Text]
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 T. Ohnishi, M. Suwa, T. Oyama, N. Arakaki, M. Torii, and Y. Daikuhara Prostaglandin E2 Predominantly Induces Production of Hepatocyte Growth Factor/Scatter Factor in Human Dental Pulp in Acute Inflammation Journal of Dental Research, February 1, 2000; 79(2): 748 - 755. [Abstract] [PDF]
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A. Garcia-Ocana, K. K. Takane, M. A. Syed, W. M. Philbrick, R. C. Vasavada, and A. F. Stewart Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia J. Biol. Chem., January 14, 2000; 275(2): 1226 - 1232. [Abstract] [Full Text] [PDF]
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S. Skrtic, K. Wallenius, A. M. Gressner, and J.-O. Jansson Insulin-Like Growth Factor Signaling Pathways in Rat Hepatic Stellate Cells: Importance for Deoxyribonucleic Acid Synthesis and Hepatocyte Growth Factor Production Endocrinology, December 1, 1999; 140(12): 5729 - 5735. [Abstract] [Full Text]
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S.-i. Hayashi, R. Morishita, S. Nakamura, K. Yamamoto, A. Moriguchi, T. Nagano, M. Taiji, H. Noguchi, K. Matsumoto, T. Nakamura, et al. Potential Role of Hepatocyte Growth Factor, a Novel Angiogenic Growth Factor, in Peripheral Arterial Disease : Downregulation of HGF in Response to Hypoxia in Vascular Cells Circulation, November 9, 1999; 100 (2009): II-301 - II-308. [Abstract] [Full Text] [PDF]
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Y. Liu Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms Am J Physiol Renal Physiol, October 1, 1999; 277(4): F624 - F633. [Abstract] [Full Text] [PDF]
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 R. Abounader, S. Ranganathan, B. Lal, K. Fielding, A. Book, H. Dietz, P. Burger, and J. Laterra Reversion of Human Glioblastoma Malignancy by U1 Small Nuclear RNA/Ribozyme Targeting of Scatter Factor/Hepatocyte Growth Factor and c-met Expression J Natl Cancer Inst, September 15, 1999; 91(18): 1548 - 1556. [Abstract] [Full Text] [PDF]
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K. Matsumoto, R. Morishita, A. Moriguchi, N. Tomita, Y. Yo, T. Nishii, K. Matsumoto, T. Nakamura, J. Higaki, and T. Ogihara Prevention of Renal Damage by Angiotensin II Blockade, Accompanied by Increased Renal Hepatocyte Growth Factor in Experimental Hypertensive Rats Hypertension, August 1, 1999; 34(2): 279 - 284. [Abstract] [Full Text] [PDF]
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M. Kato, Y. Kato, T. Nakamura, and Y. Sugiyama Efficient Extraction by the Liver Governs Overall Elimination of Hepatocyte Growth Factor in Rats J. Pharmacol. Exp. Ther., July 1, 1999; 290(1): 373 - 379. [Abstract] [Full Text]
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 T. Tamatani, K. Hattori, A. Iyer, K. Tamatani, and R. Oyasu Hepatocyte growth factor is an invasion/migration factor of rat urothelial carcinoma cells in vitro Carcinogenesis, June 1, 1999; 20(6): 957 - 962. [Abstract] [Full Text] [PDF]
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S. Yasuda, Y. Goto, H. Sumida, T. Noguchi, T. Baba, S. Miyazaki, and H. Nonogi Angiotensin-Converting Enzyme Inhibition Restores Hepatocyte Growth Factor Production in Patients With Congestive Heart Failure Hypertension, June 1, 1999; 33(6): 1374 - 1378. [Abstract] [Full Text] [PDF]
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R. Morishita, S. Nakamura, S.-i. Hayashi, Y. Taniyama, A. Moriguchi, T. Nagano, M. Taiji, H. Noguchi, S. Takeshita, K. Matsumoto, et al. Therapeutic Angiogenesis Induced by Human Recombinant Hepatocyte Growth Factor in Rabbit Hind Limb Ischemia Model as Cytokine Supplement Therapy Hypertension, June 1, 1999; 33(6): 1379 - 1384. [Abstract] [Full Text] [PDF]
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N. Arakaki, T. Kajihara, R. Arakaki, T. Ohnishi, J. A. Kazi, H. Nakashima, and Y. Daikuhara Involvement of Oxidative Stress in Tumor Cytotoxic Activity of Hepatocyte Growth Factor/Scatter Factor J. Biol. Chem., May 7, 1999; 274(19): 13541 - 13546. [Abstract] [Full Text] [PDF]
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 H. Kataoka, T. Suganuma, T. Shimomura, H. Itoh, N. Kitamura, K. Nabeshima, and M. Koono Distribution of Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1) in Human Tissues: Cellular Surface Localization of HAI-1 in Simple Columnar Epithelium and Its Modulated Expression in Injured and Regenerative Tissues J. Histochem. Cytochem., May 1, 1999; 47(5): 673 - 682. [Abstract] [Full Text]
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F. Blanquaert, A. M. Delany, and E. Canalis Fibroblast Growth Factor-2 Induces Hepatocyte Growth Factor/Scatter Factor Expression in Osteoblasts Endocrinology, March 1, 1999; 140(3): 1069 - 1074. [Abstract] [Full Text]
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D. Tulasne, R. Paumelle, K. M. Weidner, B. Vandenbunder, and V. Fafeur The Multisubstrate Docking Site of the MET Receptor Is Dispensable for MET-mediated RAS Signaling and Cell Scattering Mol. Biol. Cell, March 1, 1999; 10(3): 551 - 565. [Abstract] [Full Text]
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 L. Chin, G. Merlino, and R. A. DePinho Malignant melanoma: modern black plague and genetic black box Genes & Dev., November 15, 1998; 12(22): 3467 - 3481. [Full Text]
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K.-X. Liu, Y. Kato, I. Kino, T. Nakamura, and Y. Sugiyama Ligand-induced downregulation of receptor-mediated clearance of hepatocyte growth factor in rats Am J Physiol Endocrinol Metab, November 1, 1998; 275(5): E835 - E842. [Abstract] [Full Text] [PDF]
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L. Trusolino, L. Pugliese, and P. M. Comoglio Interactions between scatter factors and their receptors: hints for therapeutic applications FASEB J, October 1, 1998; 12(13): 1267 - 1280. [Abstract] [Full Text]
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D. A. Somerset, X.-F. Li, S. Afford, A. J. Strain, A. Ahmed, R. K. Sangha, M. J. Whittle, and M. D. Kilby Ontogeny of Hepatocyte Growth Factor (HGF) and Its Receptor (c-met) in Human Placenta : Reduced HGF Expression in Intrauterine Growth Restriction Am. J. Pathol., October 1, 1998; 153(4): 1139 - 1147. [Abstract] [Full Text] [PDF]
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J. A. Parrott and and M. K. Skinner Developmental and Hormonal Regulation of Hepatocyte Growth Factor Expression and Action in the Bovine Ovarian Follicle Biol Reprod, July 1, 1998; 59(3): 553 - 560. [Abstract] [Full Text]
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J. A. Parrott and M. K. Skinner Thecal Cell-Granulosa Cell Interactions Involve a Positive Feedback Loop among Keratinocyte Growth Factor, Hepatocyte Growth Factor, and Kit Ligand during Ovarian Follicular Development Endocrinology, May 1, 1998; 139(5): 2240 - 2245. [Abstract] [Full Text] [PDF]
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A. W. Bell, J.-G. Jiang, Q. Chen, Y. Liu, and R. Zarnegar The Upstream Regulatory Regions of the Hepatocyte Growth Factor Gene Promoter Are Essential for Its Expression in Transgenic Mice J. Biol. Chem., March 20, 1998; 273(12): 6900 - 6908. [Abstract] [Full Text] [PDF]
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J. L. Jakubczak, W. J. Larochelle, and G. Merlino NK1, a Natural Splice Variant of Hepatocyte Growth Factor/Scatter Factor, Is a Partial Agonist In Vivo Mol. Cell. Biol., March 1, 1998; 18(3): 1275 - 1283. [Abstract] [Full Text]
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M. T. Donato, M. J. Gómez-Lechón, R. Jover, T. Nakamura, and J. V. Castell Human Hepatocyte Growth Factor Down-regulates the Expression of Cytochrome P450 Isozymes in Human Hepatocytes in Primary Culture J. Pharmacol. Exp. Ther., February 1, 1998; 284(2): 760 - 767. [Abstract] [Full Text]
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M. Lyon, J. A. Deakin, H. Rahmoune, D. G. Fernig, T. Nakamura, and J. T. Gallagher Hepatocyte Growth Factor/Scatter Factor Binds with High Affinity to Dermatan Sulfate J. Biol. Chem., January 2, 1998; 273(1): 271 - 278. [Abstract] [Full Text] [PDF]
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M Yaekashiwa, S Nakayama, K Ohnuma, T Sakai, T Abe, K Satoh, K Matsumoto, T Nakamura, T Takahashi, and T Nukiwa Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study Am. J. Respir. Crit. Care Med., December 1, 1997; 156(6): 1937 - 1944. [Abstract] [Full Text]
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S. Skrtic, V. Wallenius, S. Ekberg, A. Brenzel, A. M. Gressner, and J.-O. Jansson Insulin-Like Growth Factors Stimulate Expression of Hepatocyte Growth Factor But Not Transforming Growth Factor {beta}1 in Cultured Hepatic Stellate Cells Endocrinology, November 1, 1997; 138(11): 4683 - 4689. [Abstract] [Full Text] [PDF]
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