Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Seyama, Y.
Right arrow Articles by Buzzell, G. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seyama, Y.
Right arrow Articles by Buzzell, G. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

J. Biochem, 1996, Vol. 119, No. 4 799-804
© 1996 Japanese Biochemical Society

research-article

Androgenic Control of l-Alkyl-2,3-Diacylglycerol in the Harderian Gland of the Golden Hamster, Mesocricetus auratus;1

Yousuke Seyama*,2, Azumi Hida*, Shuichiro Hayashi* and Gerald R. Buzzell{dagger}

*Department of Physiological Chemistry and Nutrition, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113
{dagger}Department of Anatomy and Cell Biology, University of Alberta Edmonton, Alberta T6G 2H7, Canada

2 To whom correspondence should be addressed. e-Mail: yseyama & at;eiyo.m.u-tokyo.ac.jp, Fax: +81(0)3-5689-2704

Harderian glands of golden hamsters produce a copious lipid secretion, most of which is in the form of l-alkyl-2,3-diacylglycerol (ADG). Sexual differences are seen in the composition of golden hamster ADG and in the morphology of secretory lipid droplet. ADGs from females contained abundant iso- and anteiso-branched chain alkyl groups and fatty acids [Seyama, Y., Otsuka, H., Ohashi, K., Vivien-Roels, B., and Pevet, P. (1995) J. Biochem, 117, 661–670]. Female hamsters were either untreated or given subcutaneous testosterone pellets. Treatment of females with testosterone led to the disappearance of such branched chain alkyl groups and fatty acids. Intact males had ADGs with entirely saturated straight chain alkyl groups and fatty acids. Castration led to the appearance of iso- and anteiso-branched chain alkyl groups and fatty acids. These observations suggested that the production of branched chain fatty acids in the Harderian gland of golden hamster is inhibited by testosterone at the step of isovaleryl-CoA dehydrogenase and 2-methyl branched-chain acyl-CoA dehydrogenase.

1 This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (YS), a grant from the Cosmetology and Research Foundation (YS), and a grant from the Natural Science and Engineering Research Council of Canada (GB).


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.