J. Biochem, 1999, Vol. 125, No. 6 1061-1066
© 1999 Japanese Biochemical Society
other |
A Fission Yeast Gene (prrl+) That Encodes a Response Regulator Implicated in Oxidative Stress Response1
Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa-ku Nagoya 464-8601
22 To whom correspondence should be addressed. Phone: +81-52-789-4089, Fax: +81-52-789-4091, E-mail: tmizuno{at}agr.nagoya-u.ac.jp
An inspection of the Schizosaccharomyces pombe genome database revealed that this eukaryotic microorganism possesses a gene that may encode a bacterial type of histidine-to-aspartate (His-Asp) phosphorelay component, namely, a response regulator. The predicted gene, named prrl+ (S.pombe response regulator), encodes a protein that contains a typical phospho-accepting receiver domain, preceded by a mammalian heat shock factor (HSF)-like DNA-binding domain. Inactivation of this prrl+ gene resulted in mutant cells defective in some aspects of stress responses, including sensitivity to oxidative stress, cold-temperature, and heavy metal toxicity. It was also demonstrated that Prrl is required for the transcription of some genes {e.g., trrl+, cttl+), which are induced by oxidative stress. These results suggest that a His-Asp phosphorelay system may be involved in a stress-activated signaling pathway in S. pombe.
This work was supported by a Grant-in-Aid (09274102) for scientific research on a priority area from the Ministry of Education, Science, Sports and Culture of Japan.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  X.-J. He, K. E. Mulford, and J. S. Fassler Oxidative Stress Function of the Saccharomyces cerevisiae Skn7 Receiver Domain Eukaryot. Cell, May 1, 2009; 8(5): 768 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Chen, C. R.M. Wilkinson, S. Watt, C. J. Penkett, W. M. Toone, N. Jones, and J. Bahler Multiple Pathways Differentially Regulate Global Oxidative Stress Responses in Fission Yeast Mol. Biol. Cell, January 1, 2008; 19(1): 308 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Vargas-Perez, O. Sanchez, L. Kawasaki, D. Georgellis, and J. Aguirre Response Regulators SrrA and SskA Are Central Components of a Phosphorelay System Involved in Stress Signal Transduction and Asexual Sporulation in Aspergillus nidulans Eukaryot. Cell, September 1, 2007; 6(9): 1570 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Takatsume, S. Izawa, and Y. Inoue Methylglyoxal as a Signal Initiator for Activation of the Stress-activated Protein Kinase Cascade in the Fission Yeast Schizosaccharomyces pombe J. Biol. Chem., April 7, 2006; 281(14): 9086 - 9092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Mutoh, M. Kawabata, and S. Kitajima Effects of Four Oxidants, Menadione, 1-Chloro-2,4-Dinitrobenzene, Hydrogen Peroxide and Cumene Hydroperoxide, on Fission Yeast Schizosaccharmoyces pombe J. Biochem., December 1, 2005; 138(6): 797 - 804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Moye-Rowley Regulation of the Transcriptional Response to Oxidative Stress in Fungi: Similarities and Differences Eukaryot. Cell, June 1, 2003; 2(3): 381 - 389. [Full Text] [PDF]
|
|
|
|
|
|
A. Greenall, A. P. Hadcroft, P. Malakasi, N. Jones, B. A. Morgan, C. S. Hoffman, and S. K. Whitehall Role of Fission Yeast Tup1-like Repressors and Prr1 Transcription Factor in Response to Salt Stress Mol. Biol. Cell, September 1, 2002; 13(9): 2977 - 2989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hohmann Osmotic Stress Signaling and Osmoadaptation in Yeasts Microbiol. Mol. Biol. Rev., June 1, 2002; 66(2): 300 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Buck, J. Quinn, T. S. Pino, H. Martin, J. Saldanha, K. Makino, B. A. Morgan, and J. B.A. Millar Peroxide Sensors for the Fission Yeast Stress-activated Mitogen-activated Protein Kinase Pathway Mol. Biol. Cell, February 1, 2001; 12(2): 407 - 419. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Aoyama, Y. Mitsubayashi, H. Aiba, and T. Mizuno Spy1, a Histidine-Containing Phosphotransfer Signaling Protein, Regulates the Fission Yeast Cell Cycle through the Mcs4 Response Regulator J. Bacteriol., September 1, 2000; 182(17): 4868 - 4874. [Abstract] [Full Text]
|
|
|
|
|
|
A. N. Nguyen, A. Lee, W. Place, and K. Shiozaki Multistep Phosphorelay Proteins Transmit Oxidative Stress Signals to the Fission Yeast Stress-activated Protein Kinase Mol. Biol. Cell, April 1, 2000; 11(4): 1169 - 1181. [Abstract] [Full Text]
|
|
|
|
 |
|
 P Thomason and R Kay Eukaryotic signal transduction via histidine-aspartate phosphorelay J. Cell Sci., January 9, 2000; 113(18): 3141 - 3150. [Abstract] [PDF]
|
|