J. Biochem, 2001, Vol. 129, No. 1 139-146
© 2001 Japanese Biochemical Society
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Isolation, Characterization, and Expression Analysis of Zebrafish Large Mafs1
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*Institute of Basic Medical Sciences, University of Tsukuba 1-1-1, Tennodai, Tsukuba 305-8575
Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST) 8916-5 Takayama, Ikoma 630-0101
Department of Biology, University of Virginia Charlottesville, VA 22903, USA
2To whom correspondence should be addressed. Phone: +81-298-53-7516, Fax: +81-298-53-6965, E-mail: satoruta{at}md.tsukuba.ac.jp
Large Maf proteins, which are members of the basic leucine zipper (b-Zip) superfamily, are involved in the determination and control of cellular differentiation. The expression patterns of various vertebrate large Maf mRNAs were described previously. Here, we report the cloning of a novel zebrafish large Maf cDNA, SMaf1 (Somite Maf1), and other zebrafish large Mafs, the N-terminus domains of which possess transactivational activity. We also analyzed the expression patterns of SMafl and SMaf2 (Somite Maf2)/Krm12 as well as MafB/Val and c-Maf during zebrafish embryogenesis. In particular, the robust expression of the novel SMafl mRNA, which overlapped that of MyoD, in somitic cells during somitogenesis was noteworthy. In addition, the expression patterns of SMaf2 and MafB in the blood-forming regions, and those of c-Maf and MafB in the lens cells showed spatial redundancy, although the temporal appearance of these genes at these sites differed. These data indicate that SMafs may play important roles in somitogenesis, and that Maf proteins may have overlapping and yet specific functions as to the determination and differentiation of cell lineages.
1This work was supported in part by a Grant-in-Aid from the Ministry of Education, Science, Sports and Culture, the Japanese Society for Promotion of Sciences (RFTF), Core Research for Evolutional Sciences and Technology (CREST), and the Program for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN).
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