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J. Biochem, 2003, Vol. 133, No. 4 397-403
© 2003 Japanese Biochemical Society

BIOCHEMISTRY

Biosynthetic Regulation and Intracellular Transport of Phosphatidylserine in Mammalian Cells

Osamu Kuge+ and Masahiro Nishijima

Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640

In mammalian cells, phosphatidylserine (PtdSer) is synthesized through the action of the endoplasmic reticulum enzymes, PtdSer synthase 1 and 2, and the decarboxylation of PtdSer accounts for the majority of phosphatidylethanolamine (PtdEtn) synthesis. PtdSer decarboxylation for PtdEtn formation occurs in the mitochondria. In addition, the transport of PtdSer from the endoplasmic reticulum to the mitochondria is probably a rate limiting step for PtdEtn synthesis through the decarboxylation pathway. Therefore, the regulation of PtdSer synthesis and its intracellular transport appear to be essential events for the maintenance of normal cellular PtdSer and PtdEtn levels. Here we describe the current understanding of the regulation of PtdSer biosynthesis and the transport of PtdSer from the ER to the mitochondria in mammalian cells.

+ To whom correspondence should be addressed. Tel: +81 3 5285-1111 (Ext. 2125), Fax: +81 3 5285-1157, E-mail: kuge{at}nih.go.jp


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