J. Biochem, 2003, Vol. 134, No. 5 631-636
© 2003 Japanese Biochemical Society
JB MINIREVIEWS |
Roles of the Intercellular Adhesion Molecule Nectin in Intracellular Signaling
Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita 565-0871
ABSTRACT
The nectin family comprises four Ca2+-independent immunoglobulin-like cell-cell adhesion molecules. Each nectin homophilically and heterophilically trans-interacts and causes intercellular adhesion, which organizes a variety of intercellular junctions in cooperation with, or independently of, cadherin. Nectin furthermore induces activation of Cdc42 and Rac small G proteins through c-Src, which eventually regulates formation of the cadherin-based adherens junctions through reorganization of the actin cytoskeleton, gene expression through activation of a mitogen-activated protein kinase cascade, and cell polarization through cell polarity proteins. We describe here the roles of nectin in intracellular signaling.
FOOTNOTES
* To whom correspondence should be addressed. Tel: +81-6-6879-3410, Fax: +81-6-6879-3419, E-mail: ytakai{at}molbio.med.osaka-u.ac.jp
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