Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Kuida, K.
Right arrow Articles by Boucher, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuida, K.
Right arrow Articles by Boucher, D. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

J. Biochem, 2004, Vol. 135, No. 6 653-656
© 2004 The Japanese Biochemical Society

JB MINIREVIEWS

Functions of MAP Kinases: Insights from Gene-Targeting Studies

Keisuke Kuida* and Diane M. Boucher

Vertex Pharmaceuticals, 130 Waverly Street, Cambridge, MA 02139, USA

Mitogen-activated protein kinases (MAPKs) comprise a family of well-conserved serine/threonine kinases that control a vast array of physiological functions in a number of organisms ranging from yeast to mammals. Recently gene-targeting experiments have shed light on in vivo functions of MAPKs. In particular, embryos deficient in extracellular signal-regulated kinase (ERK) 2 lack mesoderm differentiation and placental angiogenesis. Knockout mice for c-Jun amino-terminal kinases have revealed roles for these kinases in neural apoptosis and activation/differentiation of T cells. Deletion of p38{alpha} MAPK results in angiogenic defects in the placenta and peripheral vessels. ERK5-deficient embryos are embryonic lethal due to defects in angiogenesis and cardiovascular development. Although these results have provided new insights for MAPK research, development and analysis of conditional knockout mice are required in order to investigate roles of MAPKs, especially, in other biological processes such as disease pathogenesis.

* To whom correspondence should be addressed. Tel: +44-617-444-6100, Fax: +44-617-444-6766, E-mail: keisuke_kuida{at}vrtx.com


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BloodHome page
M. Muzio, B. Apollonio, C. Scielzo, M. Frenquelli, I. Vandoni, V. Boussiotis, F. Caligaris-Cappio, and P. Ghia
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy
Blood, July 1, 2008; 112(1): 188 - 195.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Papadaki, M. Alexiou, G. Cecena, M. Verykokakis, A. Bilitou, J. C. Cross, R. G. Oshima, and G. Mavrothalassitis
Transcriptional Repressor Erf Determines Extraembryonic Ectoderm Differentiation
Mol. Cell. Biol., July 15, 2007; 27(14): 5201 - 5213.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. R. Hamilton, S. F. Fard, F. F. Paiwand, C. Tolg, M. Veiseh, C. Wang, J. B. McCarthy, M. J. Bissell, J. Koropatnick, and E. A. Turley
The Hyaluronan Receptors CD44 and Rhamm (CD168) Form Complexes with ERK1,2 That Sustain High Basal Motility in Breast Cancer Cells
J. Biol. Chem., June 1, 2007; 282(22): 16667 - 16680.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Y. Hasegawa, J. J. Mans, S. Mao, M. C. Lopez, H. V. Baker, M. Handfield, and R. J. Lamont
Gingival Epithelial Cell Transcriptional Responses to Commensal and Opportunistic Oral Microbial Species
Infect. Immun., May 1, 2007; 75(5): 2540 - 2547.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
B.-H. Liu, T.-S. Wu, F.-Y. Yu, and C.-H. Wang
Mycotoxin Patulin Activates the p38 Kinase and JNK Signaling Pathways in Human Embryonic Kidney Cells
Toxicol. Sci., February 1, 2006; 89(2): 423 - 430.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Hayashi, C. Fearns, B. Eliceiri, Y. Yang, and J.-D. Lee
Big Mitogen-Activated Protein Kinase 1/Extracellular Signal-Regulated Kinase 5 Signaling Pathway Is Essential for Tumor-Associated Angiogenesis
Cancer Res., September 1, 2005; 65(17): 7699 - 7706.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.