© 2005 The Japanese Biochemical Society
JB MINIREVIEWS |
Versatile Role of Rab27 in Membrane Trafficking: Focus on the Rab27 Effector Families
Fukuda Initiative Research Unit, RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198
Rab27A was the only Rab protein whose dysfunction was found to cause human immunodeficiency. Since Griscelli syndrome patients (i.e., Rab27A-deficient) exhibit silvery hair color (i.e., pigmentary dilution) in addition to loss of cytotoxic killing activity by cytotoxic T lymphocytes, and Rab27A protein is expressed in a wide variety of secretory cells, Rab27A (or its closely related isoform Rab27B) has been implicated in the regulation of different types of membrane trafficking, including melanosome transport and various regulated secretion events. How does Rab27 protein regulate these different types of membrane trafficking? Recent discoveries of three different families of Rab27-binding proteins (a total of eleven distinct proteins) have supplied an important clue to the answer of this question: different types of Rab27 effectors function in different cell types. In this review I describe the literature on the identification of Rab27-binding proteins (i.e., the synaptotagmin-like protein (Slp) family with tandem C2 Ca2+-binding motifs, the Slac2 family without any C2 motifs, and Munc13-4, a putative priming factor for exocytosis) and the current state of our understanding of the molecular mechanism of the Rab27-dependent membrane trafficking.
* For correspondence: Tel: +81-48-462-4994, Fax: +81-48-462-4995; E-mail: mnfukuda{at}brain.riken.go.jp
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Tamura, N. Ohbayashi, Y. Maruta, E. Kanno, T. Itoh, and M. Fukuda Varp Is a Novel Rab32/38-binding Protein That Regulates Tyrp1 Trafficking in Melanocytes Mol. Biol. Cell, June 15, 2009; 20(12): 2900 - 2908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. D. Nightingale, K. Pattni, A. N. Hume, M. C. Seabra, and D. F. Cutler Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells Blood, May 14, 2009; 113(20): 5010 - 5018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Merrins and E. L. Stuenkel Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic {beta}-cells J. Physiol., November 15, 2008; 586(22): 5367 - 5381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kesari, M. Fukuda, S. Knoblach, R. Bashir, G. A. Nader, D. Rao, K. Nagaraju, and E. P. Hoffman Dysferlin Deficiency Shows Compensatory Induction of Rab27A/Slp2a That May Contribute to Inflammatory Onset Am. J. Pathol., November 1, 2008; 173(5): 1476 - 1487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Yu, E. Kanno, S. Choi, M. Sugimori, J. E. Moreira, R. R. Llinas, and M. Fukuda Role of Rab27 in synaptic transmission at the squid giant synapse PNAS, October 14, 2008; 105(41): 16003 - 16008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kimura, Y. Kaneko, S. Yamada, H. Ishihara, T. Senda, A. Iwamatsu, and I. Niki The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines J. Cell Sci., September 15, 2008; 121(18): 3092 - 3098. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Herrero-Turrion, J. Calafat, H. Janssen, M. Fukuda, and F. Mollinedo Rab27a Regulates Exocytosis of Tertiary and Specific Granules in Human Neutrophils J. Immunol., September 15, 2008; 181(6): 3793 - 3803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Figueiredo, C. Wasmeier, A. K. Tarafder, J. S. Ramalho, R. A. Baron, and M. C. Seabra Rab3GEP Is the Non-redundant Guanine Nucleotide Exchange Factor for Rab27a in Melanocytes J. Biol. Chem., August 22, 2008; 283(34): 23209 - 23216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fukuda, E. Kanno, K. Ishibashi, and T. Itoh Large Scale Screening for Novel Rab Effectors Reveals Unexpected Broad Rab Binding Specificity Mol. Cell. Proteomics, June 1, 2008; 7(6): 1031 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Higashio, N. Nishimura, H. Ishizaki, J. Miyoshi, S. Orita, A. Sakane, and T. Sasaki Doc2{alpha} and Munc13-4 Regulate Ca2+-Dependent Secretory Lysosome Exocytosis in Mast Cells J. Immunol., April 1, 2008; 180(7): 4774 - 4784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhu, C. Ehre, L. H. Abdullah, J. K. Sheehan, M. Roy, C. M. Evans, B. F. Dickey, and C. W. Davis Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways J. Physiol., April 1, 2008; 586(7): 1977 - 1992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-S. Wang, F.-B. Wang, Q.-G. Zhang, Z.-Z. Shen, and Z.-M. Shao Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II Mol. Cancer Res., March 1, 2008; 6(3): 372 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Gomi, K. Mori, S. Itohara, and T. Izumi Rab27b Is Expressed in a Wide Range of Exocytic Cells and Involved in the Delivery of Secretory Granules Near the Plasma Membrane Mol. Biol. Cell, November 1, 2007; 18(11): 4377 - 4386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tolmachova, M. Abrink, C. E. Futter, K. S. Authi, and M. C. Seabra Rab27b regulates number and secretion of platelet dense granules PNAS, April 3, 2007; 104(14): 5872 - 5877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. W. Handley, L. P. Haynes, and R. D. Burgoyne Differential dynamics of Rab3A and Rab27A on secretory granules J. Cell Sci., March 15, 2007; 120(6): 973 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yu, K. Kasai, K. Nagashima, S. Torii, H. Yokota-Hashimoto, K. Okamoto, T. Takeuchi, H. Gomi, and T. Izumi Exophilin4/Slp2-a Targets Glucagon Granules to the Plasma Membrane through Unique Ca2+-inhibitory Phospholipid-binding Activity of the C2A Domain Mol. Biol. Cell, February 1, 2007; 18(2): 688 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Hume, A. K. Tarafder, J. S. Ramalho, E. V. Sviderskaya, and M. C. Seabra A Coiled-Coil Domain of Melanophilin Is Essential for Myosin Va Recruitment and Melanosome Transport in Melanocytes Mol. Biol. Cell, November 1, 2006; 17(11): 4720 - 4735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Itoh and M. Fukuda Identification of EPI64 as a GTPase-activating Protein Specific for Rab27A J. Biol. Chem., October 20, 2006; 281(42): 31823 - 31831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kondo, R. Shirakawa, T. Higashi, M. Kawato, M. Fukuda, T. Kita, and H. Horiuchi Constitutive GDP/GTP Exchange and Secretion-dependent GTP Hydrolysis Activity for Rab27 in Platelets J. Biol. Chem., September 29, 2006; 281(39): 28657 - 28665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Itoh, M. Satoh, E. Kanno, and M. Fukuda Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Genes Cells, September 1, 2006; 11(9): 1023 - 1037. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. J. Holt, F. Gallo, and G. M. Griffiths Regulating secretory lysosomes. J. Biochem., July 1, 2006; 140(1): 7 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Saegusa, T. Tanaka, S. Tani, S. Itohara, K. Mikoshiba, and M. Fukuda Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells Genes Cells, June 1, 2006; 11(6): 623 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsuboi and M. Fukuda Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells J. Cell Sci., June 1, 2006; 119(11): 2196 - 2203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Mahoney, Q. Liu, T. Itoh, S. Luo, G. Hadwiger, R. Vincent, Z.-W. Wang, M. Fukuda, and M. L. Nonet Regulation of Synaptic Transmission by RAB-3 and RAB-27 in Caenorhabditis elegans Mol. Biol. Cell, June 1, 2006; 17(6): 2617 - 2625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Rondaij, R. Bierings, A. Kragt, J. A. van Mourik, and J. Voorberg Dynamics and Plasticity of Weibel-Palade Bodies in Endothelial Cells Arterioscler. Thromb. Vasc. Biol., May 1, 2006; 26(5): 1002 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsuboi and M. Fukuda The Slp4-a Linker Domain Controls Exocytosis through Interaction with Munc18-1{middle dot}Syntaxin-1a Complex Mol. Biol. Cell, May 1, 2006; 17(5): 2101 - 2112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fukuda, A. Imai, T. Nashida, and H. Shimomura Slp4-a/Granuphilin-a Interacts with Syntaxin-2/3 in a Munc18-2-dependent Manner J. Biol. Chem., November 25, 2005; 280(47): 39175 - 39184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsuboi and M. Fukuda The C2B Domain of Rabphilin Directly Interacts with SNAP-25 and Regulates the Docking Step of Dense Core Vesicle Exocytosis in PC12 Cells J. Biol. Chem., November 25, 2005; 280(47): 39253 - 39259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Baldini, A. M. Martelli, G. Tabellini, C. Horn, K. Machaca, P. Narducci, and G. Baldini Rabphilin Localizes with the Cell Actin Cytoskeleton and Stimulates Association of Granules with F-actin Cross-linked by {alpha}-Actinin J. Biol. Chem., October 14, 2005; 280(41): 34974 - 34984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Kuroda and M. Fukuda Functional Analysis of Slac2-c/MyRIP as a Linker Protein between Melanosomes and Myosin VIIa J. Biol. Chem., July 29, 2005; 280(30): 28015 - 28022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Pfeffer Structural Clues to Rab GTPase Functional Diversity J. Biol. Chem., April 22, 2005; 280(16): 15485 - 15488. [Abstract] [Full Text] [PDF]
|
|