Skip Navigation

Journal of Biochemistry 2005 137(3):243-247; doi:10.1093/jb/mvi052
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Takei, K.
Right arrow Articles by Yamada, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takei, K.
Right arrow Articles by Yamada, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2005 The Japanese Biochemical Society

Minireview

Regulatory Mechanisms of Dynamin-Dependent Endocytosis

Kohji Takei*, Yumi Yoshida and Hiroshi Yamada

Department of Neuroscience, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikatacho, Okayamashi, Okayama 700-8558

* To whom correspondence should be addressed. Phone: +81-86-235-7120, Fax: +81-86-235-7126, E-mail: kohji{at}md.okayama-u.ac.jp

ABSTRACT

Extensive studies on endocytosis in the last decade have resulted in identification of several key molecules that function in clathrin- and dynamin-dependent endocytosis. Most endocytic molecules contain multiple binding motifs that mediate protein–protein or protein–lipid interactions, which must be modulated spatially and temporally during endocytosis. Regulation of these interactions is the molecular basis of regulatory mechanisms involved in endocytosis. This review first describes current models of the mechanism of dynamin-dependent fission, then introduces several mechanisms that modulate dynamin GTPase activity and dynamin-dependent vesicle formation. Such mechanisms include regulation by inositol phospholipids, especially phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2], and their metabolism. It concludes by describing the regulation of dynamin 1 by its binding partner, amphiphysin 1, and regulation by cyclin-dependent kinase 5 (Cdk5)–dependent phosphorylation of dynamin 1 and amphiphysin 1. These mechanisms help endocytic molecules to function properly, and cooperatively regulate dynamin-dependent endocytosis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. ProteomicsHome page
S. Bidlingmaier and B. Liu
Interrogating Yeast Surface-displayed Human Proteome to Identify Small Molecule-binding Proteins
Mol. Cell. Proteomics, November 1, 2007; 6(11): 2012 - 2020.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. F. Steele, J. Eldstrom, and D. Fedida
Mechanisms of cardiac potassium channel trafficking
J. Physiol., July 1, 2007; 582(1): 17 - 26.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
P. E. MacDonald and P. Rorsman
The Ins and Outs of Secretion from Pancreatic {beta}-Cells: Control of Single-Vesicle Exo- and Endocytosis
Physiology, April 1, 2007; 22(2): 113 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
J. A. Moron, N. S. Abul-Husn, R. Rozenfeld, G. Dolios, R. Wang, and L. A. Devi
Morphine Administration Alters the Profile of Hippocampal Postsynaptic Density-associated Proteins: A Proteomics Study Focusing on Endocytic Proteins
Mol. Cell. Proteomics, January 1, 2007; 6(1): 29 - 42.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
K. Sato, M. Sato, A. Audhya, K. Oegema, P. Schweinsberg, and B. D. Grant
Dynamic Regulation of Caveolin-1 Trafficking in the Germ Line and Embryo of Caenorhabditis elegans
Mol. Biol. Cell, July 1, 2006; 17(7): 3085 - 3094.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.