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Journal of Biochemistry 2005 137(6):677-683; doi:10.1093/jb/mvi087
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© 2005 The Japanese Biochemical Society

JB Minireview

Development of the Mammalian Female Reproductive Tract

Yan Yin and Liang Ma*

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA

* To whom correspondence should be addressed. Tel: +1-314-454-8771, Fax: +1-314-454-5626, E-mail: lima{at}im.wustl.edu

The female reproductive tract (FRT), which includes the oviduct, uterus, cervix and vagina, is critical for mammalian reproduction. Recent research using knockout mice has contributed substantially to our understanding of the molecular mechanisms governing FRT development. Aside from satisfying our curiosities about the origin of life, these studies have provided us with a better understanding of FRT disorders and ways to improve female fertility. Here we review genes that are involved in various stages of sexual duct formation and development in mammals. In addition, the effect of exogenous estrogen such as DES on FRT development is also discussed.


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