Skip Navigation

Journal of Biochemistry 2005 138(1):13-19; doi:10.1093/jb/mvi098
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Kanai, Y.
Right arrow Articles by Kidokoro, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kanai, Y.
Right arrow Articles by Kidokoro, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2005 The Japanese Biochemical Society

JB Minireview

From SRY to SOX9: Mammalian Testis Differentiation

Yoshiakira Kanai*, Ryuji Hiramatsu, Shogo Matoba and Tomohide Kidokoro

Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657

* To whom correspondence should be addressed. Tel: +81-3-5841-5384, Fax: +81-3-5841-8181, E-mail: aykanai{at}mail.ecc.u-tokyo.ac.jp

Sry (sex-determining region on the Y chromosome) is a master gene that initiates testis differentiation of the bipotential indifferent gonad in mammals. In mice, Sry expression is transiently activated in a center-to-pole wave along the anteroposterior (AP) axis of developing XY gonads. Shortly after the onset of Sry activation, Sox9 (Sry-related HMG box-9), a fundamental testis-differentiation gene common to all vertebrates, is also activated in a center-to-pole pattern similar to the initial Sry expression profile. Several male-specific cellular events, such as glycogenesis, coelomic epithelium proliferation, mesonephric migration and vasculogenesis, are induced in XY gonads following the onset of Sry and Sox9 expression. This paper mainly focuses on recent advances in elucidating the regulatory mechanisms of Sry and Sox9 expression and male-specific cellular events immediately downstream of SRY action during the initial phases of testis differentiation.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
S. Dupasquier, R. Abdel-Samad, R. I. Glazer, P. Bastide, P. Jay, D. Joubert, V. Cavailles, P. Blache, and C. Quittau-Prevostel
A new mechanism of SOX9 action to regulate PKC{alpha} expression in the intestine epithelium
J. Cell Sci., July 1, 2009; 122(13): 2191 - 2196.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Hiramatsu, S. Matoba, M. Kanai-Azuma, N. Tsunekawa, Y. Katoh-Fukui, M. Kurohmaru, K.-i. Morohashi, D. Wilhelm, P. Koopman, and Y. Kanai
A critical time window of Sry action in gonadal sex determination in mice
Development, January 1, 2009; 136(1): 129 - 138.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
S. Ijiri, H. Kaneko, T. Kobayashi, D.-S. Wang, F. Sakai, B. Paul-Prasanth, M. Nakamura, and Y. Nagahama
Sexual Dimorphic Expression of Genes in Gonads During Early Differentiation of a Teleost Fish, the Nile Tilapia Oreochromis niloticus
Biol Reprod, February 1, 2008; 78(2): 333 - 341.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
H. Lin and U. W. Goodenough
Gametogenesis in the Chlamydomonas reinhardtii minus Mating Type Is Controlled by Two Genes, MID and MTD1
Genetics, June 1, 2007; 176(2): 913 - 925.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H.-S. Chang, M. D. Anway, S. S. Rekow, and M. K. Skinner
Transgenerational Epigenetic Imprinting of the Male Germline by Endocrine Disruptor Exposure during Gonadal Sex Determination
Endocrinology, December 1, 2006; 147(12): 5524 - 5541.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.