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Journal of Biochemistry 2005 138(4):457-465; doi:10.1093/jb/mvi147
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© 2005 The Japanese Biochemical Society

Regular Paper

Repression of GR-Mediated Expression of the Tryptophan Oxygenase Gene by the SWI/SNF Complex during Liver Development

Yujin Inayoshi1, Hidenori Kaneoka1, Yuichi Machida1, Masaomi Terajima1, Takeaki Dohda1, Katsuhide Miyake2,* and Shinji Iijima1

1 Department of Biotechnology, Graduate School of Engineering, and 2 Ecotopia Science Institute, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603

* To whom correspondence should be addressed. Tel: +81-52-789-4278, Fax: +81-52-789-3221, E-mail: miyake{at}proc.nubio.nagoya-u.ac.jp

The chromatin remodeling complex, SWI/SNF, is known to regulate the transcription of several genes by altering the chromatin structure in an ATP-dependent manner. SWI/SNF exclusively contains BRG1 or BRM as an ATPase subunit. In the present study, we studied the role of SWI/SNF containing BRM or BRG1 in the expression of the liver-specific tryptophan oxygenase (TO) and tyrosine aminotransferase genes. Chromatin remodeling factors significantly repressed the expression of these genes induced by glucocorticoid receptor and dexamethasone. Since the repression was not reversed by trichostatin A treatment, it seemed to be independent of the well-known histone deacetylase pathway. Knock-down of BRG1 by small interfering RNA reversed the repression in primary fetal hepatocytes. These results support a model in which SWI/SNF containing BRG1 represses late stage-specific TO gene expression at an early stage of liver development.


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