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Journal of Biochemistry 2005 138(4):501-507; doi:10.1093/jb/mvi143
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© 2005 The Japanese Biochemical Society

Regular Paper

The ER Stress Pathway Involving CHOP Is Activated in the Lungs of LPS-Treated Mice

Motoyoshi Endo1,2, Seiichi Oyadomari1, Moritaka Suga2, Masataka Mori1 and Tomomi Gotoh1,*

Departments of 1 Molecular Genetics and 2 Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Kumamoto 860-8556

* To whom correspondence should be addressed. Tel: +81-96-373-5140, Fax: +81-96-373-5145, E-mail: tomomi{at}gpo.kumamoto-u.ac.jp

CHOP is a C/EBP family transcription factor involved in endoplasmic reticulum (ER) stress-mediated apoptosis. To determine if the ER stress pathway is involved in the pathogenesis of LPS-treated mouse lung injury, mice were given lipopolysaccharide (LPS) intraperitoneally. The mRNAs for activating transcription factor (ATF) 4 and X-box binding protein (XBP) 1, transcriptional activators of the CHOP gene, and that for CHOP were induced by or after the LPS treatment. Apoptosis induced by LPS treatment was suppressed in the lungs of Chop-knockout mice. Overexpression of CHOP induced apoptosis in a lung cancer–derived cell line. These results suggest that the ER stress pathway, involving CHOP, is activated and plays a role in the pathogenesis of septic shock lung.


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