© 2006 The Japanese Biochemical Society.
JB Minireview--Membrane Traffic in Physiology and Pathology |
Overview: Membrane Traffic in Multicellular Systems: More than Just a Housekeeper
Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology (RCAI), RIKEN, Yokohama; and International Graduate School of Arts and Sciences, Yokohama City University, Yokohama
* For correspondence: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology (RCAI), RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan. Tel: +81-45-503-7031, Fax: +81-45-503-7030, E-mail: ohno{at}rcai.riken.jp
Membrane traffic is a fundamental cellular function by which molecules are transported between organelles in the post-Golgi network. Accumulating evidence supports the notion that membrane traffic is not only indispensable for normal cellular function and maintenance of cellular viability by playing housekeeping roles, but also critical for various functions characteristic of multicellular organisms. This Minireview series will focus on the latter aspects of membrane traffic. The topics discussed are: the pathophysiological impact of clathrin-associated adaptor protein (AP) complexes, the significance of membrane traffic in Alzheimer's disease, regulated exocytosis of insulin, secretory lysosomes in immune response, exosomes in physiology and pathology, viral and mammalian ubiquitin ligases modulating immune response, membrane traffic of bacterial toxins, and containment of bacterial infection by autophagy.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G.-J. Wang, Y. Liu, A. Qin, S. V. Shah, Z.-b. Deng, X. Xiang, Z. Cheng, C. Liu, J. Wang, L. Zhang, et al. Thymus Exosomes-Like Particles Induce Regulatory T Cells J. Immunol., October 15, 2008; 181(8): 5242 - 5248. [Abstract] [Full Text] [PDF]
|
|