© 2006 The Japanese Biochemical Society.
JB Minireview--Membrane Traffic in Physiology and Pathology |
Physiological Roles of Clathrin Adaptor AP Complexes: Lessons from Mutant Animals
Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology (RCAI), RIKEN, Yokohama; and International Graduate School of Arts and Sciences, Yokohama City University, Yokohama
* For correspondence: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology (RCAI), RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan. Phone: +81-45-503-7031, Fax: +81-45-503-7030, E-mail: ohno{at}rcai.riken.jp
Clathrin-associated adaptor protein (AP) complexes play a key role in the transport of proteins, by regulating the formation of transport vesicles as well as cargo selection, between organelles of the post-Golgi network, namely, the trans-Golgi network (TGN), endosomes, lysosomes and the plasma membrane. Evidence has been accumulating for the physiological importance of AP complexes. Deficiency in AP-1A or AP-2 results in embryonic lethality in mice, indicating that these AP complexes are essential for normal development of embryos in mammals. In contrast, mutations in the genes encoding subunits of AP-3A cause an autosomal recessive disorder, Hermansky-Pudlak syndrome in human and its disease models in mice. Knockout mice for the neuron-specific AP-3B suffer from epileptic seizure. Further studies on the physiological and pathological aspects of AP complexes will not only be beneficial for better understanding of developmental biology and medical sciences, but also deepen our insight into the molecular mechanisms of vesicular traffic.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  I. van den Bout and N. Divecha PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions J. Cell Sci., November 1, 2009; 122(21): 3837 - 3850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Simons, R. Al-Shawi, S. Minogue, M. G. Waugh, C. Wiedemann, S. Evangelou, A. Loesch, T. S. Sihra, R. King, T. T. Warner, et al. From the Cover: Loss of phosphatidylinositol 4-kinase 2{alpha} activity causes late onset degeneration of spinal cord axons PNAS, July 14, 2009; 106(28): 11535 - 11539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Newell-Litwa, G. Salazar, Y. Smith, and V. Faundez Roles of BLOC-1 and Adaptor Protein-3 Complexes in Cargo Sorting to Synaptic Vesicles Mol. Biol. Cell, March 1, 2009; 20(5): 1441 - 1453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Uawithya, T. Pisitkun, B. E. Ruttenberg, and M. A. Knepper Transcriptional profiling of native inner medullary collecting duct cells from rat kidney Physiol Genomics, January 17, 2008; 32(2): 229 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ohno Clathrin-associated adaptor protein complexes. J. Cell Sci., September 15, 2006; 119(Pt 18): 3719 - 3721. [Full Text] [PDF]
|
|