Skip Navigation

Journal of Biochemistry 2006 140(1):7-12; doi:10.1093/jb/mvj126
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Holt, O. J.
Right arrow Articles by Griffiths, G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holt, O. J.
Right arrow Articles by Griffiths, G. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2006 The Japanese Biochemical Society.

JB Minireview--Membrane Traffic in Physiology and Pathology

Regulating Secretory Lysosomes

Oliver J. Holt, Federico Gallo and Gillian M. Griffiths*

Sir William Dunn School of Pathology, South Parks Rd, Oxford OX1 3RE, UK

* To whom correspondence should be addressed. Tel: +44-1865-275571, Fax: +44-1865-275515, gillian.griffiths{at}path.ox.ac.uk

Secretory lysosomes are lysosomes which are capable of undergoing regulated secretion in response to external stimuli. Many cells of the immune system use secretory lysosomes to release proteins involved in their specialised effector mechanisms. Precisely how lysosomal secretion is regulated in each of these cell types is now the study of much research as these mechanisms control the ability of each of these cells to function. Studies on a number of human genetic diseases have identified some key proteins in controlling secretory lysosome release, and now many interacting partners have been identified. The different regulatory components seem to vary from one cell type to another, providing a multitude of ways for fine tuning the release of secretory lysosomes.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 FASEB J.Home page
A. Bunbury, I. Potolicchio, R. Maitra, and L. Santambrogio
Functional analysis of monocyte MHC class II compartments
FASEB J, January 1, 2009; 23(1): 164 - 171.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Nabavi, Y. Urukova, M. Cardelli, J. E. Aubin, and R. E. Harrison
Lysosome Dispersion in Osteoblasts Accommodates Enhanced Collagen Production during Differentiation
J. Biol. Chem., July 11, 2008; 283(28): 19678 - 19690.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
N. Lahat, M. A. Rahat, A. Kinarty, L. Weiss-Cerem, S. Pinchevski, and H. Bitterman
Hypoxia enhances lysosomal TNF-{alpha} degradation in mouse peritoneal macrophages
Am J Physiol Cell Physiol, July 1, 2008; 295(1): C2 - C12.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Higashio, N. Nishimura, H. Ishizaki, J. Miyoshi, S. Orita, A. Sakane, and T. Sasaki
Doc2{alpha} and Munc13-4 Regulate Ca2+-Dependent Secretory Lysosome Exocytosis in Mast Cells
J. Immunol., April 1, 2008; 180(7): 4774 - 4784.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
E Rudd, Y T Bryceson, C Zheng, J Edner, S M Wood, K Ramme, S Gavhed, A Gurgey, M Hellebostad, A G Bechensteen, et al.
Spectrum, and clinical and functional implications of UNC13D mutations in familial haemophagocytic lymphohistiocytosis
J. Med. Genet., March 1, 2008; 45(3): 134 - 141.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. J. Charette and P. Cosson
A LYST/beige homolog is involved in biogenesis of Dictyostelium secretory lysosomes
J. Cell Sci., July 15, 2007; 120(14): 2338 - 2343.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.