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Journal of Biochemistry Advance Access originally published online on March 4, 2007
Journal of Biochemistry 2007 141(5):621-626; doi:10.1093/jb/mvm068
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© 2007 The Japanese Biochemical Society.

c-Abl Tyrosine Kinase Activates p21 Transcription Via Interaction with p53

Yuqi Jing*, Min Wang*, Wen Tang, Tianyang Qi, Chunsheng Gu, Shui Hao and Xianlu Zeng{dagger}

Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China

{dagger}To whom correspondence should be addressed. Tel: 86-431-5099317, Fax: 86-431-5687517, E-mail: zengx779{at}nenu.edu.cn

Received December 18, 2006; Accepted February 12, 2007


  Abstract

c-Abl non-receptor tyrosine kinase has been implicated in many cellular processes including cell differentiation, stress response and regulating gene transcription. The mechanism by which c-Abl is involved in the regulation of gene transcription remains to be elucidated. In this study, we investigated the functions of c-Abl in the activation of p21 promoter. Our results showed that overexpression of c-Abl tyrosine kinase activated p21 promoter and endogenous p21 transcription in U2OS cells. We found that p53 is involved in the activation of p21 promoter by c-Abl, and integrative structure of p53 is required for regulating p21 transcription. In addition, the chromatin immunoprecipitation study demonstrated that c-Abl and p53 can be recruited to the region containing p53 binding site of p21 promoter, and c-Abl increases the DNA binding activity of p53 to the p21 promoter. Furthermore, not only the activation of p21 promoter but also the recruitment to p21 promoter by c-Abl is dependent on the interaction between c-Abl and p53 protein.

Key Words: c-abl tyrosine kinase, gene transcription, p21, p53

*The two authors contributed equally to this work.


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