Skip Navigation


Journal of Biochemistry Advance Access originally published online on March 4, 2007
Journal of Biochemistry 2007 141(5):669-674; doi:10.1093/jb/mvm069
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
141/5/669    most recent
mvm069v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Yin, F.
Right arrow Articles by Wang, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yin, F.
Right arrow Articles by Wang, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 The Japanese Biochemical Society.

Effects of Triethylene Tetraamine on the G-quadruplex Structure in the Human c-myc Promoter

Fei Yin1,2, Jianhui Liu1,*, Xiaohong Deng1 and Jingyun Wang3

1Research Center of Pharmaceutical Chemistry & Chemobiology, Chongqing Technology and Business University; 2College of Environment and Bioengineering, Chongqing Technology and Business University, Chongqing 400067, China; and 3College of Environment and Bioengineering, Dalian University of Technology, Dalian 116023, China

*To whom correspondence should be addressed. Tel: 86-23-6276-9652, Fax: 86-23-6276-9652, E-mail: jhliu{at}dlut.edu.cn

Received February 8, 2007; Accepted February 22, 2007


  Abstract

The increasing data show that a parallel G-quadruplex structure formed by the element of nuclease-hypersensitivity element III1 (NHE III1) in the P1 promoter of c-myc functions as a transcriptional repressor. Triethylene tetraamine has exhibited interesting properties of stabilizing both inter- and intra-molecular G-quadruplex structures and telomerase-inhibitory potency. Here, we present evidences showing that triethylene tetraamine facilitates the formation of G-quadruplex structure by the NHE III1 element, and inhibits the expression of c-myc in HeLa cells.

Key Words: c-Myc, G-quadruplex, telomerase, triethylene tetraamine

Abbreviations: TETA, triethylene tetraamine; CD, circular dichroism; NHE, nuclease-hypersensitivity element


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.