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Journal of Biochemistry Advance Access originally published online on June 13, 2007
Journal of Biochemistry 2007 142(1):1-10; doi:10.1093/jb/mvm122
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© 2007 The Japanese Biochemical Society.

JB Minireviews-Genome Decoding Systems

Regulation of GATA1 Gene Expression

Makoto Kobayashi1,2,* and Masayuki Yamamoto1,2,3

1Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences; 2ERATO Environmental Response Project, Japan Science and Technology Agency, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575; and 3Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan

*To whom correspondence should be addressed. Tel: +81-29-853-8457, Fax: +81-29-853-5977, E-mail: makobayash{at}md.tsukuba.ac.jp

Received May 12, 2007; Accepted June 7, 2007


  Abstract

GATA1 is one of the most fascinating transcription factors for biologists. It regulates many haematopoietic genes and interacts with a number of other transcription factors. Its functions are mostly conserved among vertebrates. Upon disruption of the GATA1 gene, mice show a drastic bloodless phenotype. GATA1 knockdown mice are predisposed to tumour development, the extent of which varies depending on the level of knockdown. When GATA1 is overexpressed, certain cells face an altered cell fate. These observations suggest the importance of regulation on the expression level and timing of GATA1. Deciphering such regulation is the key to understanding the commitment and differentiation of blood cells. There are so many splendid reviews describing GATA1 as a transcription factor. We therefore focus our topics on GATA1 gene regulation in this review.

Key Words: cell differentiation, gene expression level, haematopoiesis, lineage determination, transcription factor

Abbreviations: BFU-E, burst-forming units-erythroid; CFU-E, colony-forming units-erythroid; ChIP, chromatin immunoprecipitation; CLP, common lymphoid progenitor; CMP, common myeloid progenitor; EEP, early erythroid progenitor; ES, embryonic stem; G1HE, GATA1 gene haematopoietic enhancer; G1HRD, GATA1 haematopoietic regulatory domain; G1TAR, GATA1 testis activation region; GMP, granulocyte/monocyte progenitor; HSC, haematopoietic stem cell; KLF, Krüppel-like factor; LCR, locus control region; LEP, late erythroid progenitor; MEP, megakaryocyte/erythrocyte lineage-restricted progenitor; ProE, proerythroblast


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