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Journal of Biochemistry Advance Access originally published online on June 13, 2007
Journal of Biochemistry 2007 142(1):11-15; doi:10.1093/jb/mvm123
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© 2007 The Japanese Biochemical Society.

JB Minireviews-Genome Decoding Systems

Cross-talks between Transcription and Post-transcriptional Events within a ‘mRNA Factory’

Masatoshi Hagiwara1,2,* and Takayuki Nojima1,2,3

1Department of Functional Genomics, Medical Research Institute; 2Laboratory of Gene Expression, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan; and 3The 21st Century Center of Excellence (COE) Program for the Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone

*To whom correspondence should be addressed. Tel: +81-3-5803-5836, Fax: +81-3-5803-5853, E-mail: m.hagiwara.end{at}mri.tmd.ac.jp

Received March 28, 2007; Accepted June 1, 2007


  Abstract

Eukaryotic gene expression is controlled in multi steps. Pre-messenger RNAs (pre-mRNAs) transcribed by RNA polymerase II (RNAPII) are capped at 5' end, spliced to remove introns and polyadenylated at 3' end. These processes are followed by other post-transcriptional steps that include mRNA export, translation and mRNA degradation. Recent studies have shown that individual events occurring during eukaryotic gene expression are coupled together under more elaborate regulatory controls. In this review, the molecular and functional cross-talks between transcription and the post-transcriptional events are overviewed.

Key Words: export, mRNA factory, RNA processing, splicing, transcription

Abbreviations: CBC, cap-binding complex; CE, capping enzyme; ChIP, chromatin immunoprecipitation; CPSF, cleavage/polyadenylation-specific factor; CTD, the carboxyl terminal domain of the largest subunit of RNA polymerase II; EJC, exon-junction complex; MLP, adenovirus major late promoter; mRNP, mRNA-protein complex; NMD, nonsense-mediated mRNA decay; REF, RNA and export factor binding proteins; RNAPII, RNA polymerase II; TREX, transcription/export (complex)


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