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Journal of Biochemistry Advance Access originally published online on November 1, 2007
Journal of Biochemistry 2008 143(1):1-8; doi:10.1093/jb/mvm204
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© 2007 The Japanese Biochemical Society.

JB Review

Messenger RNA Surveillance Systems Monitoring Proper Translation Termination

Nobuyoshi Akimitsu*

Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba-shi, Ibaraki 305-8566, Japan

*To whom correspondence should be addressed. Tel: +81-29-861-6085, Fax: +81-29-861-6095, E-mail: nobu.akimitsu{at}aist.go.jp

Received July 6, 2007; Accepted September 26, 2007


  Abstract

Organisms have evolved an elaborate set of quality control systems to ensure the fidelity of the genetic information flow. The mRNA surveillance systems work in this context by monitoring the quality of mRNAs to ensure that they are suitable for translation. In this review, recent achievements in the investigation of mRNA surveillance pathways, including nonsense-mediated mRNA decay and nonstop-mediated mRNA surveillance pathway, will be discussed.

Key Words: mRNA quality control, mRNA surveillance, ribosome, stop codon, translation

Abbreviations: NMD, nonsense-mediated mRNA decay; PTC, premature termination codon; EJC, exon-exon junction complex


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