Journal of Biochemistry Advance Access originally published online on November 16, 2007
Journal of Biochemistry 2008 143(4):441-448; doi:10.1093/jb/mvm222
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© 2007 The Japanese Biochemical Society.
JB Minireview-Functional Dynamics of the Nucleus |
The Structure and Functions of NPM1/Nucleophsmin/B23, a Multifunctional Nucleolar Acidic Protein
Graduate School of Comprehensive Human Sciences and Basic Medical Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575 and PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi-shi, Saitama, 332-0012, Japan
*To whom corespondence should be addressed. Tel: +81-29-853-3472, Fax: +81-29-853-3472, E-mail: mokuwaki{at}md.tsukuba.ac.jp
Received October 2, 2007; Accepted November 3, 2007
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Abstract |
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NPM1/Nucleophosmin/B23, also termed NO38 or numatrin, is an acidic nucleolar protein that plays multiple roles in cell growth and proliferation. In general, the expression level of B23 is proportional to the cell growth rate, suggesting that it plays a positive role(s) in cell growth and proliferation. It is important to note that the deletion of the B23 gene and expression of an aberrant type of this gene—caused by gene conversion via translocation or reading-frame shift via nucleotides insertion—have been observed in diverse haematopoietic malignancies. Thus, it is important to understand the function of B23 in the regulation of cell growth and proliferation. In addition, B23 has been reported to undergo a variety of post-translational modifications such as phosphorylation, ubiquitination, SUMOylation, acetylation and poly-(ADP-ribosyl)ation. In this review, the basic structure and functions of B23 as well as the regulation of these functions are summarized.
Key Words: histone chaperone, nucleoplasmin, nucleolus, phosphorylation, RNA
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