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Journal of Biochemistry Advance Access originally published online on April 4, 2008
Journal of Biochemistry 2008 144(1):87-93; doi:10.1093/jb/mvn045
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© 2008 The Japanese Biochemical Society

Carbon Fibre Composites: Integrated Electrochemical Sensors for Wound Management

Duncan Sharp*, Stephen Forsythe and James Davis

School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK

*To whom correspondence should be addressed. Tel: +44 (0) 115 848 3218, Fax: +44(0) 115 848 6616, E-mail: duncan.sharp{at}ntu.ac.uk

Received January 21, 2008; Accepted March 18, 2008


  Abstract

The applicability of employing a carbon fibre mesh as an electrochemical sensing substructure for assessing urate transformations within wound exudates is evaluated. Prototype sensor assemblies have been designed and their response characteristics towards uric acid and other common physiological components are detailed. Modification of the carbon fibre sensor through surface anodization and the application of cellulose acetate permselective barriers have been shown to lead to optimized responses and much greater sensitivity (1440% increase) and specificity. These could enable the accurate periodic monitoring of uric acid in wound fluid. The performance characteristics of the composite sensors in whole blood, serum and blister fluid have been investigated.

Key Words: carbon fibre, smart bandage, urate, uric acid, wound infection

Abbreviations: HAI, hospital acquired infection; ROS, reactive oxygen species


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