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J. Biochem, 1967, Vol. 62, No. 3 339-344
© 1967 Japanese Biochemical Society

research-article

Effects of ACTH and Whole-body X-irradiation on the Concentratic of Enzymes, Nicotinainide Nudeotides and Cytochromes in Rat-adrenal

NAGASUGAMI YAGO, SABURO OMATA, SHIGERU KOBAYASHI and SHOGO ICHII

From the Physiology Laboratory, National Institute of Radiological Sciences Chiba

1.The levels of DNA, RNA, protein, nicotinamide nucleotides, enzymes and cytochromes P-450 and b5 in rat-adrenals were determined 24 hours after a single injection of ACTH (10 units) and 24, 48 and 72 hours after whole-body X-irradiation at a lethal dose (1,000 r).

2. At these times, adrenal nuclei showed abnormally high RNA polymerase activity.

3.The concentrations of nicotinamide nucleotides did not change during the experimental periods.

4. In mithochondria, succinate dehydrogenase [EC 1.3.99.1 [EC] ] increased rather abruptly 72 hours after X-irradiation, while NADHt cytochrome c reductase decreased significantly during the experimental periods. P-450 was increased after 24 hours but was significantly decreased after 48 and 72 hours. NADPHj cytochrome c reductase remained unchanged after 24 and 48 hours but had decreased after 72 hours.

5. In microsomes, cytochrome 45 and NADH2 cytochrome c reductase decreased significantly after ACTH and X-irradiation. P-450 and NADPHj cytochrome c reductase remained at the control levels, with a temporary increase of the former 24 hours after X-irradiation.


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