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J. Biochem, 1968, Vol. 64, No. 2 167-170
© 1968 Japanese Biochemical Society

research-article

The Interaction of Pinacyanol* and Quinoline-1-Oxides,** with Nucleic Acids: The Base Specificity of Binding

MASAHIKO KODAMA, YUSAKU TAGASHIRA and CHIKAYOSHI NAGATA

From the Biophysics Division, National Cancer Center Research Institute Chuo-ku, Tokyo

Base specificity of pinacyanol which has been shown to interact with DNA orienting perpendicularly to the base planes, was studied by means of the difference spectrum method. Purine bases in DNA were found to be more preferable than pyrimidine bases for the attachment site of pinacyanol. The same was true for the nucleosides.

The base specificity of carcinogenic 4-nitroquinoline-l-oxide (4-NQO) and 4-hydroxyaminoquinoline 1-oxide (4-HAQO) was studied, and in this case also, purine bases were more effective in binding with these carcinogens. There was no difference in binding capacity between adenosine and guanosine.

*Presented partly at the 38th Annual Meeting of the Japanese Biochemical Society held in Fukuoka in October, 1965.

**Presented partly at the 24th Annual Meeting of the Japanease Cancer Association held in Fukuoka in October 1965


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