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J. Biochem, 1974, Vol. 76, No. 4 861-869
© 1974 Japanese Biochemical Society

research-article

Structural Studies on Anti-inflammatory Polysaccharides from Streptomyces fradiae

Hitoshi ARITA, Hiroshige TSUZUKI, Kazuyuki MORIHARA and Jun'ichi KAWANAMI

Shionogi Research Laboratory, Shionogi & Co., Ltd. Fukushima-ku, Osaka 553

Two kinds of L-arabinans have been isolated from a broth of Streptomyces fradiae 3739 strain. Both of these arabinans, named P-1 and P-2, possess potential anti-carrageenin abscess activity. Chromatographic differences on TEAE-cellulose between P-1 and P-2 can be attributed to differences in the contents of D-galacturonic acid in these polysaccharides. From the results of various experiments, it is concluded that these L-arabinans have almost linear structures made up of 1->5 linked {alpha}-L-arabinofuranose units. D-Galacturonic acid was found to be linked to L-arabinose by an {alpha}-glycosidic linkage. The molecular weights of P-1 and P-2 were determined to be 9,800 and 4,700, respectively, by ultracentrifugal analyses. Periodate oxidation of these polysaccharides resulted in loss of biological activity.


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