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J. Biochem, 1976, Vol. 79, No. 6 1147-1155
© 1976 Japanese Biochemical Society

research-article

Properties of Liposomal Membranes Composed of Short-Chain Lecithins

Takayuki KITAGAWA1, Keizo INOUE2 and Shoshichi NOJIMA2

Department of Chemistry, National Institute of Health Kamiosaki, Shinagawa-ku, Tokyo 142

Permeability properties of multilamellar liposomes prepared from synthetic, saturated short-chain (C8, C10, C12) lecithins (3-sn-phosphatidyl choline) were studied. Dioctanoyl-lecithin, didecanoyllecithin, and dilauroyllecithin form "stable" bilayers which are practically impermeable to glucose when prepared with proportions of more than 1.2, 0.75, and 0.6 of cholesterol (molar ratio to phospholipid), respectively. Dioctanoyl-lecithin liposomes were rather leaky above 30°, even when a proportion of 1.5 of cholesterol (molar ratio to lecithin) was incorporated. Judging from their sensitivities to temperature, Triton X-100, serum albumin, and other reagents, short-chain lecithin bilayers show characteristic properties, different from those of both saturated long-chain lecithins (dipalmitoyllecithin and dimyristoyllecithin) and lecithins having unsaturated fatty acid residues (egg lecithin and dioleoyllecithin).

1Present address: Department of Virology, Institute of Medical Sciences, University of Tokyo, Minato-ku, Tokyo 108.

2Present address: Department of Health Chemistry, Faculty of Pharamaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113.


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