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J. Biochem, 1976, Vol. 80, No. 2 291-297
© 1976 Japanese Biochemical Society

research-article

Involvement of Cyclic GMP in the Initial Stage of Hepatocytes Proliferation1

Yoshiaki MIURA, Hajime IWAI2, Ryuichi SAKATA3, Hidesato OHTSUKA, EZRA Elhanan4, Keiko KUBOTA and Noriko FUKUI

Department of Biochemistry, Chiba University School of Medicine Chiba, Chiba 280

A transient rise in cyclic guanosine 3' : 5' monophosphate (c-GMP) in the liver was observed in rats in vivo 10–20 min after partial hepatectomy. A similar increase in c-GMP in the liver was also found in rats in vivo 15 min after infusion of TGH solution (a mixture of triiodothyronine, glucagon, and heparin). In both cases, inductions of ornithine decarboxylase [EC 4. 1. 1. 17] and tyrosine aminotransferase [EC 2. 6. 1. 5] were found 4 hr after the beginning of the experiments. Later, 22 hr after the surgical intervention or hormone infusion, thymidine kinase [EC 2. 7. 1. 21] was activated and liver slices were able to incorporate [3H]thymidine into DNA. These biochemical phenomena were observed commonly in regenerating liver as well as in the liver of rats infused with TGH solution. c-GMP, but not c-AMP, could induce ornithine decarboxylase and tyrosine aminotransferase in isolated, perfused liver.

1 This study was supported in part by a grant for scientific research from the Ministry of Education, Science and Culture, of Japan and by a research grant from the Naito Foundation.

2 Present address: Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd., Toda, Saitama 335.

3 Present address: Department of Brain Surgery, Tokyo Medical College, Shinjuku-ku, Tokyo 160.

4 On leave from the Department of Biological Chemistry, The Hebrew University of Jerusalem, Israel.


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