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J. Biochem, 1976, Vol. 80, No. 2 309-313
© 1976 Japanese Biochemical Society

research-article

Regulation of Chicken Erythrocyte AMP Deaminase by Phytic Acid1

Masataka YOSHINO*, Yasuhiko KAWAMURA**, Kazue FUJISAWA** and Nobuaki OGASAWARA***

*Department of Biochemistry, Yokohama City University School of Medicine Minami-ku, Yokohama, Kanagawa 232
**Department of Biochemistry, School of Medicine, Nagoya University Showa-ku, Nagoya, Aichi 466
***Department of Biochemistry, Institute for Developmental Research Aichi Prefecture Colony, Kasugai, Aichi 486

AMP deaminase [EC 3.5.6.4 [EC] ] purified from chicken erythrocytes was inhibited by phytic acid (inositol hexaphosphate), which is the principal organic phosphate in chicken red cells. Kinetic analysis has indicated that this inhibition is of an allosteric type. The estimated K1 value was within the normal range of phytic acid concentration, suggesting that this compound acts as a physiological effector. Divalent cations such as Ca2+ and Mg2+ were shown to affect AMP deaminase by potentiating inhibition by lower concentrations of phytic acid, and by relieving the inhibition at higher concentrations of phytic acid. These results suggests that Ca2+ and Mg2+ can modify the inhibition of AMP deaminase by phytic acid in chicken red cells.

* This study was supported in part by a grant from the Ministry of Education, Science and Culture, of Japan.


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