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J. Biochem, 1976, Vol. 80, No. 2 397-399
© 1976 Japanese Biochemical Society

other

Generation of the Superoxide Radical during Autoxidation of Oxymyoglobin

Toshio GOTOH* and Keiji SHIKAMA**

*Department of Biology, College of General Education, University of Tokushima Tokushima, Tokushima 770
**Biological Institute, Faculty of Science, Tohoku University Sendai, Miyagi 980

Autoxidation of bovine oxymyoglobin to metmyoglobin induces co-oxidation of epinephrine to adrenochrome. This co-oxidation is markedly inhibited by superoxide dismutase [EC 1.15.1.1 [EC] ]. Electron transfer from oxymyoglobin to ferricytochrome c is partially inhibited by superoxide dismutase. These results indicate that autoxidation of oxymyoglobin results in generation of superoxide radicals. Autoxidation of oxymyoglobin is accelerated by superoxide dismutase and partially inhibited by catalase [EC 1.11.1.6 [EC] ].


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