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J. Biochem, 1978, Vol. 83, No. 3 693-698
© 1978 Japanese Biochemical Society

research-article

Galactose Metabolism in Dictyostelium discoideum

Regulation of Galactose-1-Phosphate-Uridyl Transferase during Growth and Development

David C. DeMEGLIO and Thomas B. FRIEDMAN1

Department of Biological Sciences, Oakland University Rochester, Michigan 48063, U.S.A.

Dictyostelium discoideum is able to metabolize [l-14C]galactose to 14CO2 despite the observation that galactose is inhibitory with respect to growth. Galactose-1-phosphate uridyl transferase activity is present throughout growth and development and varies in activity only slightly during the entire life cycle of D. discoideum, in contrast to the rapid increase in UDP-glucose 4-epimerase activity during development. Therefore, in D. discoideum, these two enzymes of the Leloir pathway are independently regulated, unlike E. coli where these enzymes are co-ordinately controlled.

1 To whom reprint requests should be sent new address: Department of Zoology, Michigan State University East Lansing, Michigan 48824, U.S.A.


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