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J. Biochem, 1978, Vol. 83, No. 3 799-805
© 1978 Japanese Biochemical Society

research-article

Isolation of 3ß, 7{alpha}-Dihydroxychol-5-Enoic Acid, an Intermediate of Chenodeoxycholic Acid Biogenesis, and 3{alpha}, 7{alpha}-Dihydroxychol-4-Enoic Acid from Bladder Bile of Hens

Mitsunori IKEDA and Kazumi YAMASAKI1

Department of Biochemistry, Kawasaki Medical School 577 Matsushima, Kurashiki, Okayama 701–01

Two Lifschütz-positive C24-bile acids were isolated from bladder bile of hens. One of these was identified by isotope dilution experiments after conversion to a 3H-labeled compound, and also by GLC after methoxylation, as 3ß, 7{alpha}-dihydroxychol-5-enoic acid, a key intermediate of chenodeoxycholic acid biogenesis. The other, to which the structure 3ß, 7{alpha}-dihydroxychol-4-enoic acid had been assigned previously, was proved to be its 3{alpha}-epimer by several experiments.

These findings favor the alternative pathway of chenodeoxycholic acid biogenesis proposed by Yamasaki and his associates.

1Visiting Profesor of Kawasaki Medical School.


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