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J. Biochem, 1978, Vol. 83, No. 3 887-892
© 1978 Japanese Biochemical Society

research-article

Role of Phospholipid in Adrenaline-Induced Lipolysis and Cyclic AMP Production

Hiromichi OKUDA, Yasushi SAITO*, Nobuo MATSUOKA*, Etsuko TAKEDA and Akira KUMAGAI*

2nd Department of Medical Biochemistry, School of Medicine, Ehime University Onsen-gun, Ehime 791-02
*2nd Department of Internal Medicine, School of Medicine, Chiba University Chiba, Chiba 280

Lipid micelles consisting of a glyceride mixture (triolein, diolein, and monoolein) and lecithin bound adrenaline-14C more strongly than did micelles consisting of the glyceride mixture only. Lipid micelles consisting of the glyceride mixture and phosphatidic acid also bound adrenaline-14C effectivily, whereas lipid micelles consisting of the glyceride mixture and diglyceride, obtained from lecithin, did not bind the hormone strongly. Both phenoxybenzamine (an {alpha}blocker) and propranolol (a ß-blocker) strongly inhibited the association between adrenaline-14C and lipid micelles consisting of the glyceride mixture and lecithin. Propranolol, inhibited adrenaline-induced lipolysis in both fat cells and fat globules, whereas, phenoxybenzamine, did not affect adrenaline-induced lipolysis. Both agents reduced adrenaline-induced adenylcyclase activation in fat cell ghosts. Phospholipid was also found to be related with adrenaline-mediated adenylcyclase activation.


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