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J. Biochem, 1979, Vol. 86, No. 1 111-119
© 1979 Japanese Biochemical Society

research-article

Modulation of Glycosaminoglycan Synthesis during Cell Growth as Observed in an Embryonic Chick Tendon Cell Culture1

Yoshifumi NINOMIYA and Yutaka NAGAI

Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University Kanda-surugadai, Chiyoda-ku, Tokyo 101

Glycosaminoglycan synthesis during cell growth has been studied in terms of unit cell numbers, using 16-day-old embryonic chick tendon cell cultures. Hyaluronic acid production was found to be inversely proportional to the cell density, while the levels of sulfated-glycosaminoglycan synthesis remained constant. On the other hand, hyaluronic acid production remained constant during cell proliferation, though chondroitin sulfate synthesis increased rapidly during an actively growing phase of the cultured cells, and dermatan sulfate and heparan sulfate syntheses increased gradually.

1This work was supported in part by Scientific Research Grants from the Ministry of Education, Science and Culture of Japan (238011 and 244075).


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