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J. Biochem, 1980, Vol. 87, No. 4 1071-1077
© 1980 Japanese Biochemical Society

research-article

The Amino Acid Sequence of a Salivary Proline-Rich Peptide, P-C, and Its Relation to a Salivary Proline-Rich Phosphoprotein, Protein C

Satoko ISEMURA, Eiichi SAITOH and Kazuo SANADA

Department of Oral Biochemistry, Nippon Dental University Niigata Faculty Niigata, Niigata 951

A basic proline-rich peptide, P-C, was isolated from human whole saliva and its amino acid sequence was determined to be Gly-Arg-Pro-Gln-Gly-Pro-Pro-Gln-Gln-Gly-Gly-His-Gln-Gln-Gly-Pro-Pro-Pro-Pro-Pro-Pro-Gly-Lys-Pro-Gln-Gly-Pro-Pro-Pro-Gln-Gly-Gly-Arg-Pro-Gln-Gly-Pro-Pro-Gln-Gly-Gln-Ser-Pro-Gln.

P-C was also found to be present in stimulated parotid saliva. The sequence determined appears to correspond to the C-terminal 44 residues of a proline-rich phosphoprotein, Protein C, the partial sequence of which has been elucidated, and suggests that P-C might be derived from Protein C.


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