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J. Biochem, 1980, Vol. 87, No. 4 1249-1252
© 1980 Japanese Biochemical Society

other

Age-Related Response of Tryptophan Pyrrolase to 17ß-Estradiol in the Liver of Female Rats

Swaraj K. PATNAIK1 and Sitikanta SARANGI

Biochemistry Laboratory, Department of Zoology, Banaras Hindu University Varanasi 221005, India

The activity and the induction pattern of tryptophan pyrrolase in the liver of female rats of various ages were studied with a view to investigate the mechanism of aging in relation to enzyme regulation. The level of this enzyme increases gradually upto 33-week and decreases significantly thereafter with increasing age. Estradiol induces this enzyme significantly in both the normal and ovariectomized rats of all the ages. However, the degree of induction is different in different age groups. Highest degree of induction is observed in mature (13-week) rats. Induction of the enzyme by estradiol is actinomycin D-sensitive.

1 Present address: Biochemistry Division, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221005, India.


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