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J. Biochem, 1982, Vol. 91, No. 6 2013-2019
© 1982 Japanese Biochemical Society

research-article

Developmental Profiles of Glycolipids in Mouse Small Intestine1

Eiji SATO*, Tadayoshi UEZATO**, Michiya FUJTTA** and Kenji NISHIMURA*

*Department of Biology, Hamamatsu University School of Medicine Handacho 3600, Hamamatsu, Shizuoka 431–31
**Department of Biochemistry, Hamamatsu University School of Medicine Handacho 3600, Hamamatsu 431-31

The major gangliosides were isolated from small intestine of 2-week-old mice of C3H/He strain and identified as GM3, GM1, and GDla. These gangliosides characteristically contained a phytosphingosine moiety and a-hydroxy fatty acids. The gangliosides contained both N-glycolylneuraminic acid and N-acetylneuraminic acid. Gangliosides GM3, GM1, and GDla contents increased in mouse small intestine during the suckling period, and decreased after weaning. In contrast, neutral glycosphingohpids appeared after weaning, except for monohexosyl ceramide, which was present at a fairly constant level throughout postnatal life. The same results were obtained with mice of other strains and germ-free ICR mice, although such changes could not be observed in rats. These observations indicate that the developmental change in the composition of glycosphingolipids occurs in a species-specific manner.

1This work was supported in part by a grant from the Ministry of Education, Science and Culture of Japan.


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