Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by YANAGAWA, H.
Right arrow Articles by EGAMI, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by YANAGAWA, H.
Right arrow Articles by EGAMI, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

J. Biochem, 1982, Vol. 91, No. 6 2087-2090
© 1982 Japanese Biochemical Society

other

Novel Formation of {alpha}-Amino Acids and Their Derivatives from Oxo Acids and Ammonia in an Aqueous Medium

Hiroshi YANAGAWA, Yumiko MAKINO, Kazuki SATO, Masato NISHIZAWA and Fujio EGAMI

Mitsubishi-Kasei Institute of Life Sciences 11 Minamiooya, Machida, Tokyo 194

In the course of a study of chemical evolution in the primeval sea, a novel reaction of carbonyl compounds with ammonia was found. Glyoxylic acid reacted with ammonia to afford N-oxalylglycine, which gave glycine in a 3–20 % yield after 6 n HC1 hydrolysis. Similarly, glyoxylic acid was treated with methylamine to give N-oxalylsarcosine, which afforded sarcosine in a 9–12% yield upon hydrolysis. Pyruvic acid reacted with ammonia to give N-acetylalanine, which gave alanine in a 1–4% yield upon hydrolysis. These reactions provide a novel and facile route to a-amino acids and their derivatives. A mechanism for the reactions is proposed.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.