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J. Biochem, 1982, Vol. 92, No. 3 835-838
© 1982 Japanese Biochemical Society

research-article

Peripheral Distribution of Nervous System-Specific S-100 Prote'n in Rat

Fujiko SUZUKI*, Takashi NAKAJIMA** and Kanefusa KATO*,1

*Department of Biochemistry, Institute for Developmental Research, Aichi Prefectural Colony Kamiya, Kasugai, Aichi 480–03
**Pathology Division, National Cancer Research Institute Chuo-ku, Tokyo 104

1To whom reprint requests should be addressed at Department of Biochemistry, Institute for Developmental Research, Aichi Prefectural, Colony, Kamiya, Kasugai, Aichi 480-03.

S-100 protein, a nervous system-specific protein, was determined in a soluble extract of various rat tissues with a sensitive enzyme immunoassay method, which consisted of a solid-phase with immobilized anti-S-100 antibody and the antibody labeled with ß-D-galactosidase from Escherichia coli. The minimum detectable amount of S-100 protein was 3 pg/assay. Central nervous tissues (cerebrum, cerebellum, and brain stem) contained 1.4 to 2.8 µg S-100 protein/mg protein, whereas most of the peripheral tissues contained less than 0.05 µg/ml of the specific protein. However, the level of S-100 protein was high in adipose tissue (0.5–1.1 µg/mg) and in trachea (about 0.5µg/mg), which involves cartilage. The S-100 protein levels in several tissues were significantly higher in female rats than in males at ages of 5 to 6 weeks.


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