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J. Biochem, 1984, Vol. 96, No. 4 1297-1301
© 1984 Japanese Biochemical Society

research-article

Synthesis and Protective Effects of Poly-8-Bromoriboadenylic Acid: Poly Ribouridylic Acid Hybrid against Wesselsbron Virus in Chick Embryos

Joseph Ololade FOLAYAN1, Oluokun Alamu Oluboade OYEDAPO and Felix Ononsolease Bob AKOJIE

Biochemistry Department, University of Ife, Ile-Ife, Oyo State Nigeria

1To whom correspondences be sent.

Poly-8-bromoriboadenylic acid was synthesized by the bromination of adenosine-5'-monophosphate to yield 8-bromoadenosine-5'-monophosphate which on conversion to the 5'-diphosphate form was polymerized by polynucleotide phosphorylase (PNPase). The polymer formed a 1 : 1 hybrid with polyribouridylic acid and the hybrid was found to protect chick embryos against Wesselsbron virus (H10964 [GenBank] ).


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