J. Biochem, 1984, Vol. 96, No. 4 1311-1314
© 1984 Japanese Biochemical Society
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Cystatin S: A Cysteine Proteinase Inhibitor of Human Saliva
*Department of Oral Biochemistry, Niigata Faculty, Nippon Dental University Niigata 951
**First Department of Internal Medicine, Niigata University School of Medicine Niigata 951
***Department of Biochemistry, Tohoku University School of Medicine Sendai, Miyagi 980
An acidic protein of human saliva, which we named SAP-1 previously, is now shown to be an inhibitor of several cysteine proteinases. The protein inhibited papain and ficin strongly, and stem bromelain and bovine cathepsin C partially. However, it did not inhibit either porcine cathepsin B or clostripain. The mode of the inhibition of papain was found to be non-competitive. The name cystatin S has been proposed for this salivary protein in view of the similarities in activity and structure to other cysteine proteinase inhibitors such as chicken egg-white cystatin and human cystatins A, B, and C. The cystatin S antigen was detected immunohistochemically in the serous cells of human parotid and submaxillary glands.
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