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J. Biochem, 1984, Vol. 96, No. 5 1559-1564
© 1984 Japanese Biochemical Society

research-article

Inversions in Mitochondrial DNA of a Petite Mutant of Yeast

Kazuhiko WAKABAYASHI* and Yasuji FURUTANI**,1

*Department of Biochemistry, Medical School, The University of Yamanashi Tamaho, Nakakoma, Yamanashi 409-38
**Department of Microbiology, Shizuoka College of Pharmacy Oshika, Shizuoka, Shizuoka 422

Mitochondrial DNA of an erythromycin-resistant petite mutant of yeast, E734, showed physical maps of inversion, which occurred between two cross-over sites in the fragments Hae A and Hae B. The pair of cross-over sites was inferred to be accommodated within a repeat unit of E734 mtDNA during petite mutation by joining two fragments excised from non-adjacent region of wild type mtDNA.

1 Present address: Dainippon Pharmaceutical Co., Osaka.


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