J. Biochem, 1986, Vol. 99, No. 5 1541-1544
© 1986 Japanese Biochemical Society
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One of the Antigenic Determinants of Paired Helical Filaments Is Related to Tau Protein1
*Department of Neurology, Institute of Brain Research, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113 Nagasaki, Nagasaki 852
**Tokyo Metropolitan Institute of Gerontology Itabashi-ku, Tokyo 173
3 To whom reprint requests should be addressed.
Paired helical filaments (PHF) are unusual neuronal fibers which accumulate progressively in the brain in Alzheimer's disease (AD). The insolubility of PHF in various kinds of solvents enabled us to obtain highly purified PHF, but prevented the application of conventional analytical methods to identify their components. Here we report that antibodies against purified PHF recognize tau protein, a brainspecific microtubule-associated protein, suggesting that a portion of PHF is tau protein.
1 This work was supported in part by a grant from the Ministry of Education, Science and Culture of Japan.
2 Present address: Center for Neurologic Diseases, Biosciences Research Building, Brigham and Women's Hospital, Boston, MA 02115.
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